Different oil migration patterns for Mississippian oil in the Western Plains Region of North America are the result of changes in source area, structure, oil gravity, permeability, and hydraulic head through time. The objective of this study is to model oil migration pathways in the Mississippian Mission Canyon Formation of the Madison Group by recreating paleohydraulic head and paleostructure maps for the Santonian, Paleocene and Eocene stages. The Mission Canyon Formation is the primary carrier bed for lateral migration of Mississippian/ Devonian oil into younger strata, and likely occurred along subcrop boundaries and through fractures in close vicinity to the current accumulation. At a regional scale it is the lateral flow paths that are of interest in tracing source areas and identifying potential exploration fairways.