The Murzuk Basin of southwest Libya is one of several incratonic sag basins present in north Africa. The main petroleum reservoir of the Murzuk is the upper Ordovician Memouniat Formation sandstone. The primary source rock in the basin is the Silurian Tanezzuft Formation. The charge and flushing history of the basin is highly complex. The study aims to inform future exploration strategies by using petroleum migration modelling to better understand oil migration patterns and fushing risk.